Reduksin and Reduksin Light for weight loss - application, instructions, reviews. Reduksin and Reduksin Light for weight loss - application, instructions, reviews Reduksin: side effects

08.03.2022

Reduxin (Sibutramine + Microcrystalline Cellulose) is a drug for getting rid of excess body fat, realizing its therapeutic potential due to the combined action of its constituent components. Sibutramine becomes a true drug only after metabolic transformations in the biological environment of the body. Active metabolites of the drug - primary and secondary amines - inhibit the reuptake of neurotransmitters serotonin and norepinephrine. An increase in the concentration of the latter in the synapses of nerve endings activates serotonin 5-hydroxytryptamine receptors and adrenoreceptors, which, in turn, contributes to the development of a feeling of satiety, a decrease in the psychological need for food, and an increase in heat production. By stimulating beta-3-adrenergic receptors, sibutramine acts on adipose tissue (the so-called "brown fat"). A decrease in the proportion of adipose tissue in the body composition is accompanied by an increase in the level of high density lipoproteins (the so-called “good cholesterol”) in the blood, while a decrease in the concentration of triglycerides, low density lipoproteins (“bad cholesterol”), total cholesterol and uric acid.

Being a pronounced enterosorbent, microcrystalline cellulose has good absorption capacity and detoxification properties. Absorbs and provides elimination from the body of various pathogens, exogenous and endogenous toxins, allergens, as well as potentially toxic metabolites.

After oral administration, Reduxin is rapidly and in a significant (about 80%) volume absorbed in the digestive tract.

It undergoes the effect of the first passage through the liver (it is at this stage that the active metabolites of the drug are formed). The half-life of sibutramine is about 1 hour, its active metabolites are 14-16 hours. The drug is excreted mainly by the kidneys. Multiplicity of reception of Reduksin - 1 time per day. The dose in each case is determined by the doctor, observing the individual reaction of the patient's body in the initial phase of the therapeutic course. As such a trial dose, 10 mg is used, with observed adverse reactions to the drug, the dose is halved, and if individual intolerance is confirmed, it is canceled. The optimal time of admission is in the morning, after waking up, but if necessary, Reduxin can also be taken with food at a later time. If in the first month of drug therapy body weight decreased by less than 5%, then the dose is increased by 1.5 times (up to 15 mg). The duration of the therapeutic course in the absence of positive results should not exceed 90 days. If, according to its results, a decrease in body weight by more than 5% was not achieved, the treatment is considered unsuccessful. The same conclusion follows in the event that the patient, after the initial weight loss, begins to gain weight again (3 or more kg). The total duration of taking Reduxin should not exceed two years, since this drug is relatively young, and so far there has not been enough information about its efficacy and safety. Taking Reduxin, you must adhere to a balanced diet and devote enough time to physical exercise.

Pharmacology

Combined drug for the treatment of obesity, the action of which is due to its constituent components. Sibutramine is a prodrug and exerts its effect in vivo through metabolites (primary and secondary amines) that inhibit the reuptake of monoamines (mainly serotonin and norepinephrine). An increase in the content of neurotransmitters in the synapses increases the activity of central serotonin 5-HT receptors and adrenoreceptors, which contributes to an increase in satiety and a decrease in the need for food, as well as an increase in thermal production. Indirectly activating β 3 -adrenergic receptors, sibutramine acts on brown adipose tissue. Weight loss is accompanied by an increase in the concentration of HDL in the blood serum and a decrease in the amount of triglycerides, total cholesterol, LDL, and uric acid.

Sibutramine and its metabolites do not affect the release of monoamines, do not inhibit MAO; do not have affinity for a large number of neurotransmitter receptors, including serotonin (5-HT 1 , 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C), adrenoreceptors (β 1 , β 2 , β 3 , α 1, α 2), dopamine (D 1 , D 2), muscarinic, histamine (H 1), benzodiazepine and NMDA receptors.

Microcrystalline cellulose is an enterosorbent, has sorption properties and a nonspecific detoxification effect. It binds and removes from the body various microorganisms, their metabolic products, toxins of exogenous and endogenous nature, allergens, xenobiotics, as well as an excess of some metabolic products and metabolites responsible for the development of endogenous toxicosis.

Pharmacokinetics

Absorption, distribution, metabolism

After taking the drug inside, sibutramine is rapidly absorbed from the gastrointestinal tract, not less than 77%. It undergoes a "first pass" effect through the liver and is biotransformed with the participation of cytochrome P450 isoenzyme 3A4 to form two active metabolites (mono- and didesmethylsibutramine). After taking a single dose of 15 mg C max monodesmethylsibutramine is 4 ng / ml (3.2-4.8 ng / ml), didesmethylsibutramine - 6.4 ng / ml (5.6-7.2 ng / ml). C max sibutramine is reached after 1.2 hours, active metabolites - after 3-4 hours. Taking it simultaneously with food reduces C max of metabolites by 30% and increases the time it is reached by 3 hours without changing AUC. Rapidly distributed into tissues. The binding of sibutramine to plasma proteins is 97%, and mono- and didesmethylsibutramine is 94%. C ss of active metabolites in the blood is achieved within 4 days after the start of treatment and is approximately 2 times higher than the plasma level after taking a single dose.

breeding

T 1/2 sibutramine - 1.1 h, monodesmethylsibutramine - 14 h, didesmethylsibutramine - 16 h. Active metabolites undergo hydroxylation and conjugation to form inactive metabolites, which are excreted mainly by the kidneys.

Release form

Capsules No. 2 blue; the contents of the capsules are white or white with a slightly yellowish tint powder.

Excipients: calcium stearate.

The composition of the capsule shell: titanium dioxide dye, azorubine dye, patent blue dye, gelatin.

10 pieces. - blister packs (aluminum/PVC) (3) - cardboard packs.
10 pieces. - cellular contour packings (aluminum/PVC) (6) - packs of cardboard.

Dosage

Reduksin ® is prescribed orally 1 time / day. The dose is set individually, depending on tolerability and clinical efficacy. The recommended initial dose is 10 mg, with poor tolerance, a dose of 5 mg can be taken. Capsules should be taken in the morning without chewing and drinking plenty of liquid. The drug can be taken on an empty stomach or combined with food intake.

If a weight loss of 5% or more is not achieved within 4 weeks from the start of treatment, then the dose is increased to 15 mg / day. The duration of therapy with Reduxin should not exceed 3 months in patients who do not respond well enough to therapy (i.e., who fail to reduce weight by 5% of the initial body weight within 3 months of treatment). Treatment should not be continued if, with further therapy (after achieved weight loss), the patient again gains 3 kg or more in body weight.

The total duration of therapy should not exceed 2 years, since there are no data on efficacy and safety for a longer period of taking sibutramine.

Therapy with Reduxin should be carried out by a doctor with practical experience in the treatment of obesity. The drug should be combined with diet and exercise.

Overdose

There are extremely limited data on overdose of sibutramine. In case of overdose, the patient should consult a doctor.

Symptoms: may increase the severity of side effects. Specific signs of overdose are unknown.

Treatment: taking activated charcoal, gastric lavage, symptomatic therapy, with an increase in blood pressure and tachycardia - the appointment of beta-blockers. There is no specific treatment or specific antidotes. It is necessary to perform general measures: ensure free breathing, monitor the state of the cardiovascular system, and, if necessary, carry out supportive symptomatic therapy. The effectiveness of forced diuresis or hemodialysis has not been established.

Interaction

Inhibitors of microsomal oxidation, incl. inhibitors of cytochrome P450 isoenzyme 3A4 (including ketoconazole, erythromycin, cyclosporine) increase plasma concentrations of sibutramine metabolites with an increase in heart rate and a clinically insignificant increase in the QT interval. Rifampicin, macrolide antibiotics, phenytoin, carbamazepine, phenobarbital and dexamethasone can accelerate the metabolism of sibutramine. The simultaneous use of several drugs that increase the content of serotonin in the blood can lead to the development of a serious interaction. The so-called serotonin syndrome can develop in rare cases with the simultaneous use of Reduxin with selective serotonin reuptake inhibitors (drugs for the treatment of depression), with some drugs for the treatment of migraine (sumatriptan, dihydroergotamine), with potent analgesics (pentazocine, pethidine, fentanyl) or antitussives. drugs (dextromethorphan). Sibutramine does not affect the effect of oral contraceptives.

With the simultaneous administration of sibutramine and ethanol, there was no increase in the negative effect of ethanol. However, the use of alcohol is absolutely not combined with the dietary measures recommended when taking sibutramine.

Side effects

Side effects, depending on the impact on organs and organ systems, are presented in the following order (often -> 10%, sometimes - 1-10%, rarely -< 1%).

From the side of the central nervous system and peripheral nervous system: often - dry mouth, insomnia; sometimes - headache, dizziness, anxiety, paresthesia, and changes in taste; in isolated cases - back pain, depression, drowsiness, emotional lability, anxiety, irritability, nervousness, convulsions.

One patient with schizoaffective disorder thought to have existed prior to treatment developed acute psychosis after treatment.

Since the cardiovascular system: sometimes - tachycardia, palpitations, increased blood pressure, vasodilation. There is a moderate rise in blood pressure at rest by 1-3 mm Hg. and a moderate increase in heart rate of 3-7 beats per minute. In some cases, more pronounced increases in blood pressure and heart rate are not excluded. Clinically significant changes in the level of blood pressure and pulse are recorded mainly at the beginning of treatment (in the first 4-8 weeks).

From the digestive system: often - loss of appetite, constipation; sometimes - nausea, exacerbation of hemorrhoids. With a tendency to constipation in the early days, it is necessary to control the evacuation function of the intestine. If constipation occurs, stop taking and take a laxative. In isolated cases, abdominal pain, a paradoxical increase in appetite, a transient increase in liver enzymes.

Dermatological reactions: sometimes - sweating; in isolated cases - skin itching, Shenlein-Genoch purpura (hemorrhages in the skin).

On the part of the body as a whole: in isolated cases, the following clinically significant adverse events are described: dysmenorrhea, edema, flu-like syndrome, thirst, rhinitis, acute interstitial nephritis, bleeding, thrombocytopenia.

Withdrawal reactions such as headache or increased appetite are rare. There is no evidence that after treatment there is an abstinence syndrome, withdrawal syndrome or mood disorders.

Most often, side effects occur at the beginning of treatment (in the first 4 weeks). Their severity and frequency weaken over time. Side effects are generally mild and reversible.

Indications

For weight loss in the following conditions:

alimentary obesity with a body mass index (BMI) of 30 kg/m 2 or more;
alimentary obesity with a BMI of 27 kg / m 2 or more in combination with other risk factors due to overweight (type 2 diabetes mellitus / non-insulin-dependent / or dyslipoproteinemia).

Contraindications

the presence of organic causes of obesity (for example, hypothyroidism);
severe eating disorders (anorexia nervosa or bulimia nervosa);
mental illness;
Gilles de la Tourette syndrome (generalized tics);
simultaneous reception of MAO inhibitors (for example, phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine) or their use within 2 weeks before the appointment of the drug Reduxin ® ; the use of other drugs acting on the central nervous system (for example, antidepressants, antipsychotics); drugs prescribed for sleep disorders containing tryptophan, as well as other centrally acting drugs for weight loss;
coronary artery disease, decompensated chronic heart failure, congenital heart disease, peripheral arterial occlusive disease, tachycardia, arrhythmia, cerebrovascular disease (stroke, transient cerebrovascular accident);
uncontrolled arterial hypertension (BP above 145/90 mm Hg);
thyrotoxicosis;
severe liver dysfunction;
severe renal dysfunction;
benign prostatic hyperplasia;
pheochromocytoma;
angle-closure glaucoma;
established drug, drug or alcohol addiction;
pregnancy;
lactation (breastfeeding);
children and adolescents up to 18 years of age;
old age over 65;
established hypersensitivity to sibutramine or to other components of the drug.

The drug should be prescribed with caution in the following conditions: arrhythmias in history, chronic circulatory failure, coronary artery disease (including history), cholelithiasis, arterial hypertension (controlled and in history), neurological disorders, including mental retardation and convulsions (including in history), impaired liver and / or kidney function of mild to moderate severity, motor and verbal tics in history.

Application features

Use during pregnancy and lactation

The drug should not be used during pregnancy due to the lack of a sufficiently convincing number of studies on the safety of the effects of sibutramine on the fetus.

Women of childbearing age should use contraceptives while taking Reduxin.

Reduxin ® should not be used during breastfeeding.

Application for violations of liver function

It is contraindicated in severe hepatic impairment. With caution, the drug should be prescribed for impaired liver function of mild to moderate severity.

Application for violations of kidney function

Contraindicated in severe renal impairment. With caution, the drug should be prescribed for impaired renal function of mild to moderate severity.

Use in children

Contraindicated in children and adolescents under 18 years of age.

special instructions

Reduxin ® should be used only in cases where all non-drug measures to reduce body weight are ineffective - if the weight loss within 3 months was less than 5 kg.

Treatment with Reduxin should be carried out as part of complex therapy for weight loss under the supervision of a physician with practical experience in the treatment of obesity.

Comprehensive therapy for obesity includes both diet and lifestyle changes and increased physical activity. An important component of therapy is the creation of prerequisites for a stable change in dietary habits and lifestyle, which are necessary to maintain the achieved weight loss even after discontinuation of drug therapy. Patients need to change their lifestyle and habits as part of therapy with Reduxin ® in such a way that, after completion of treatment, the achieved weight loss is maintained. Patients should clearly understand that failure to comply with these requirements will lead to a repeated increase in body weight and repeated visits to the attending physician.

In patients taking Reduxin ® , it is necessary to measure blood pressure and heart rate. In the first 2 months of treatment, these parameters should be monitored every 2 weeks, and then monthly. In patients with arterial hypertension (who have blood pressure levels above 145/90 mm Hg during antihypertensive therapy), this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients in whom blood pressure twice exceeded the level of 145/90 mm Hg during repeated measurement. treatment with Reduxin ® should be suspended.

Particular attention should be paid to the simultaneous administration of drugs that increase the QT interval. These drugs include blockers of histamine H 1 receptors (astemizole, terfenadine); antiarrhythmic drugs that increase the QT interval (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol); Gastrointestinal motility stimulants (cisapride, pimozide, sertindole and tricyclic antidepressants). Caution should be observed when using the drug against the background of conditions that are risk factors for an increase in the QT interval (hypokalemia, hypomagnesemia).

The interval between taking MAO inhibitors and Reduxin should be at least 2 weeks.

The relationship between taking Reduxin and the development of primary pulmonary hypertension has not been established, however, given the well-known risk of drugs in this group, with regular medical monitoring, special attention should be paid to symptoms such as progressive dyspnea (breathing disorder), chest pain and swelling in the legs.

Influence on the ability to drive vehicles and control mechanisms

Taking the drug Reduxin ® may limit the patient's ability to drive vehicles and control mechanisms.

In this article, you can read the instructions for using the drug Reduxin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Reduxin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Reduksin in the presence of existing structural analogues. Use for the treatment of alimentary obesity and weight loss, including during pregnancy and lactation.

Reduxin- a combined drug for the treatment of obesity, the action of which is due to its constituent components. Reduxin (its active substance Sibutramine) is a prodrug and exerts its effect in vivo due to metabolites (primary and secondary amines) that inhibit the reuptake of monoamines (mainly serotonin and norepinephrine). An increase in the content of neurotransmitters in the synapses increases the activity of central serotonin 5-HT receptors and adrenoreceptors, which contributes to an increase in satiety and a decrease in the need for food, as well as an increase in thermal production. Indirectly activating beta3-adrenergic receptors, sibutramine acts on brown adipose tissue. Weight loss is accompanied by an increase in the concentration of HDL in the blood serum and a decrease in the amount of triglycerides, total cholesterol, LDL, and uric acid.

Reduxin and its metabolites do not affect the release of monoamines, do not inhibit MAO; do not have affinity for a large number of neurotransmitter receptors, including serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), adrenoreceptors (beta1, beta2, beta3, alpha1, alpha2), dopamine (D1, D2), muscarinic, histamine (H1), benzodiazepine and NMDA receptors.

Compound

Reduxin consists of two components:

sibutramine hydrochloride monohydrate
cellulose microcrystalline

Pharmacokinetics

After taking the drug inside, sibutramine is rapidly absorbed from the gastrointestinal tract, not less than 77%. Active metabolites undergo hydroxylation and conjugation to form inactive metabolites, which are excreted primarily by the kidneys.

Indications

For weight loss in the following conditions:

alimentary obesity with a body mass index (BMI) of 30 kg/m2 or more;
alimentary obesity with a BMI of 27 kg / m2 or more in combination with other risk factors due to overweight (type 2 diabetes mellitus / non-insulin-dependent / or dyslipoproteinemia).

Release forms

Dosage form in the form of tablets of the drug Reduxin does not exist. If somewhere you met a mention of pills - do not believe it, this is a fake, which can be dangerous to your health.

Capsules 10 and 15 mg.

Reduxin Light - capsules 625 mg.

Instructions for use

Reduxin is prescribed orally 1 time per day. The dose is set individually, depending on tolerability and clinical efficacy. The recommended initial dose is 10 mg, with poor tolerance, a dose of 5 mg can be taken. Capsules should be taken in the morning without chewing and drinking plenty of liquid. The drug can be taken on an empty stomach or combined with food intake.

If within 4 weeks from the start of treatment a decrease in body weight by 5% or more is not achieved, then the dose is increased to 15 mg per day. The duration of therapy with Reduxin should not exceed 3 months in patients who do not respond well enough to therapy (i.e., who fail to reduce weight by 5% of the initial body weight within 3 months of treatment). Treatment should not be continued if, with further therapy (after achieved weight loss), the patient again gains 3 kg or more in body weight.

The total duration of therapy should not exceed 2 years, since there are no data on efficacy and safety for a longer period of taking sibutramine.

Therapy with Reduxin should be carried out by a doctor with practical experience in the treatment of obesity. The drug should be combined with diet and exercise.

Differences Reduksina Light

Unlike the usual Reduxin Light, the form is a dietary supplement (BAA) and is sold at any pharmacy without a prescription.

Side effect

dry mouth, insomnia;
headache, dizziness;
anxiety;
paresthesia;
depression;
drowsiness;
emotional lability, anxiety, irritability, nervousness;
convulsions;
tachycardia, palpitations;
increase in blood pressure;
loss of appetite;
constipation;
nausea;
sweating;
skin itching;
dysmenorrhea;
swelling;
flu-like syndrome;
bleeding;
thrombocytopenia.

Most often, side effects occur at the beginning of treatment (in the first 4 weeks). Their severity and frequency weaken over time. Side effects are generally mild and reversible.

Contraindications

the presence of organic causes of obesity (for example, hypothyroidism);
severe eating disorders (anorexia nervosa or bulimia nervosa);
mental illness;
Gilles de la Tourette syndrome (generalized tics);
simultaneous reception of MAO inhibitors (for example, phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine) or their use within 2 weeks before the appointment of the drug Reduxin; the use of other drugs acting on the central nervous system (for example, antidepressants, antipsychotics); drugs prescribed for sleep disorders containing tryptophan, as well as other centrally acting drugs for weight loss;
coronary artery disease, decompensated chronic heart failure, congenital heart disease, peripheral arterial occlusive disease, tachycardia, arrhythmia, cerebrovascular disease (stroke, transient cerebrovascular accident);
uncontrolled arterial hypertension (BP above 145/90 mm Hg);
thyrotoxicosis;
severe liver dysfunction;
severe renal dysfunction;
benign prostatic hyperplasia;
pheochromocytoma;
angle-closure glaucoma;
established drug, drug or alcohol addiction;
pregnancy;
lactation (breastfeeding);
children and adolescents up to 18 years of age;
old age over 65;
established hypersensitivity to sibutramine or to other components of the drug.

Use during pregnancy and lactation

The drug should not be used during pregnancy due to the lack of a sufficiently convincing number of studies on the safety of the effects of sibutramine on the fetus.

Women of childbearing age should use contraceptives while taking Reduxin.

Reduxin should not be used during breastfeeding.

special instructions

Reduxin should be used only in cases where all non-drug measures to reduce body weight are ineffective - if the weight loss for 3 months was less than 5 kg.

Treatment with Reduxin should be carried out as part of complex therapy for weight loss under the supervision of a physician with practical experience in the treatment of obesity.

Comprehensive therapy for obesity includes both diet and lifestyle changes and increased physical activity. An important component of therapy is the creation of prerequisites for a stable change in dietary habits and lifestyle, which are necessary to maintain the achieved weight loss even after discontinuation of drug therapy. As part of Reduxin therapy, patients need to change their lifestyle and habits in such a way that, after completion of treatment, the achieved weight loss is maintained. Patients should clearly understand that failure to comply with these requirements will lead to a repeated increase in body weight and repeated visits to the attending physician.

In patients taking Reduxin, it is necessary to measure blood pressure and heart rate. In the first 2 months of treatment, these parameters should be monitored every 2 weeks, and then monthly. In patients with arterial hypertension (who have blood pressure levels above 145/90 mm Hg during antihypertensive therapy), this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients in whom blood pressure twice exceeded the level of 145/90 mm Hg during repeated measurement. treatment with Reduxin should be suspended.

The interval between taking MAO inhibitors and Reduxin should be at least 2 weeks.

Influence on the ability to drive vehicles and control mechanisms

Taking the drug Reduxin may limit the patient's ability to drive vehicles and control mechanisms.

drug interaction

With the simultaneous administration of sibutramine and ethanol (alcohol), there was no increase in the negative effect of ethanol. However, the use of alcohol is absolutely not combined with the dietary measures recommended when taking sibutramine.

Analogues of the drug Reduksin

Structural analogues for the active substance:

Reduxin Light

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Reduxin is a combination drug for weight loss, in a complex effect it reduces appetite, enhances the feeling of fullness and thermogenesis, and helps to break down body fat.

The active ingredient of the drug - sibutramine hydrochloride monohydrate - effectively contributes to an increase in the decrease in a person's need for food, and also enhances "heat production", which contributes to the breakdown of fats and the use of incoming calories, and not their deposition. Secondarily activating β3-adrenergic receptors, the active substance also affects heavy brown fats. Weight loss is accompanied by an increase in the concentration of HDL in the blood and a decrease in the content of triglycerides, cholesterol, LDL and uric acid.

The second active component of Reduxin is microcrystalline cellulose - it is she who is responsible for creating a feeling of fullness, a full stomach. In the stomach, cellulose swells, absorbing water and toxic substances (as an absorbent), filling the volume of the stomach. Therefore, while taking Reduxin, it is recommended to drink clean water.

The drug is presented in pharmacies in the form of capsules of two different colors - they differ in the level of content of active ingredients. Blue-colored Reduxin contains 10 mg of sibutramine and 158.5 mg of microcrystalline cellulose, and blue-colored Reduxin contains 15 and 153.5 mg, respectively.

It is important that gradual weight loss gives a big positive boost to the body. After all, in the stomach there are receptors that, when filled with food, give a signal to the brain about saturation. Due to the gradual reduction in calorie content and the amount of food consumed, which is inevitable when taking Reduxin, the stomach gradually shrinks in size, adjusting to new portions. Gradually, the “normal” amount of necessary food is also reduced, and a person develops a persistent habit of eating less for all the time. And even after stopping the course of therapy, this effect naturally persists for a long time and can be saved by you to maintain mass at the current level.

It is important to understand that Reduxin should be taken only if the diet and non-drug measures to reduce body fat have not had an effect - weight loss over 3 months was less than 5 kg.

Indications for use

Reduxin is prescribed exclusively for weight loss, in the following cases:

Alimentary obesity with a body mass index (BMI) of 30 kg/m2 or more;
Alimentary obesity with a BMI of 27 kg/m2 or more in combination with other risk factors caused by overweight - type 2 diabetes mellitus / non-insulin-dependent / or dyslipoproteinemia.

Application instruction Reduksin, dosages

The drug is taken 1 time per day in the morning (before or during breakfast), without chewing and drinking plenty of liquid.

At the beginning of the course of treatment, a dosage of 10 mg, Reduxin blue capsule, should be used. In case of side effects or feeling unwell, the dosage should be reduced to 5 mg over 4 weeks. Then we go back to 10 mg.

The total time of taking Reduxin should not exceed 3 months, in case of insufficient effectiveness of the therapy - that is, if it is not possible to reduce body weight by 5% of the initial value. If during treatment, upon reaching a given body weight, the effect of gradual weight gain begins to be observed, the drug should be stopped.

The total duration of the use of Reduxin should not exceed 1 year, since longer use of the drug has not been studied.

It is important that Reduxin is taken under the supervision of a physician with practical experience in the treatment of obesity. It is more effective to take the medication in conjunction with diet and exercise.

The effect of the drug in elderly patients does not differ from that in other age groups.

If you miss taking Reduxin, do not take a double dosage next time - this may lead to the development of side effects. Just continue further taking the drug according to the previous scheme.

Contraindications and side effects

The main contraindications for treatment with Reduxin:

the presence of organic causes of obesity (for example, hormonal disorders);
severe eating disorders (anorexia nervosa or bulimia nervosa);
mental illness, Gilles de la Tourette syndrome;
simultaneous reception of MAO inhibitors or their use within 2 weeks before the appointment of the drug Reduxin;
the use of drugs acting on the central nervous system (for example, antidepressants, antipsychotics); drugs prescribed for sleep disorders containing tryptophan, as well as other centrally acting drugs for weight loss;
IHD, decompensated CHF, congenital heart defects, occlusive diseases of peripheral arteries;
tachycardia, arrhythmias, stroke, transient disorders of cerebral circulation;
uncontrolled arterial hypertension (BP above 145/90 mm Hg);
thyrotoxicosis;
severe violations of the liver or kidneys;
benign prostatic hyperplasia;
pheochromocytoma;
angle-closure glaucoma;
established drug, drug or alcohol addiction;
pregnancy and breastfeeding;
children and adolescents up to 18 years of age;
individual sensitivity to the active substance or to other components of Reduxin.

Under the following conditions, the drug should be prescribed only under the supervision of a physician: hypertension, mental retardation and convulsions (including history), motor and verbal tics in history.

Side effects

Since Reduxin binds water in the stomach, some of the most common side effects are dry mouth, lack of appetite, constipation and sleep disturbance.

Additionally, disorders such as dizziness, headache, nausea, anxiety, taste disturbance, increased blood pressure, tachycardia, acute forms of hemorrhoids and increased sweating can be observed.

Reception Reduksin can cause some other side effects:

Psychosis, a state with a suicidal direction of thinking and suicide - when such symptoms appear, the drug is immediately stopped;
diarrhea and vomiting;
Baldness;
The appearance of short-term memory impairment and seizures;
Violation of urination;
Violation of the field of vision;
impotence, problems with ejaculation and orgasm;
The occurrence of uterine bleeding and menstruation disorders;
Various allergic reactions - skin rashes, urticaria, itching, anaphylaxis, Quincke's edema.

Very rarely, a withdrawal reaction can be observed; at the end of the course of taking the drug, it is a headache or increased appetite. There are no data on the identification of withdrawal symptoms or mood disorders.

The most common side effects of Reduxin occur at the initial stage (in the first 4 weeks of treatment). Gradually, their severity decreases, if this does not happen, the possibility of discontinuing or replacing the drug should be considered.

Overdose

Symptoms of an overdose are manifested in an increase in the severity of side effects.

Symptomatic treatment - it is necessary to take absorbents and monitor vital functions, with an increase in blood pressure and heart rate - the appointment of beta-blockers.

It is recommended to follow general measures: unbutton the collar and open the window - ensure free breathing, monitor pressure and pulse. The effectiveness of forced diuresis or hemodialysis has not been clinically established.

Analogues Reduksin, list of drugs

Among the analogues of Reduxin, the following drugs can be distinguished, the list:

Lindax;
Meridia;
Slimia;
Goldline;

It is important to understand that the instructions for use of Reduxin, the price and reviews do not apply to analogues and cannot be used as a guide for the use of drugs of similar composition or action. All therapeutic appointments must be made by a doctor. When replacing Reduxin with an analog, it is important to get expert advice, you may need to change the course of therapy, dosages, etc. Do not self-medicate!

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Reduxin

Instruction

Reduxin- This is a weight loss remedy, which recently appeared on the pharmaceutical market. Since the question how to lose weight ?"has always been considered relevant, and the ideal means to achieve this goal has not yet been invented, then interest in the drug arose long before its release, from the moment when the first information about it appeared.

Release form

The drug is available in the form of capsules of 10 mg and 15 mg.

Compound

The composition of the drug includes sibutramine, which is used in complex therapy in the treatment of obesity. This drug differs from Reduxina Light- that contains conjugated linoleic acid and is a harmless food additive.

Indications

The main indication for use: complex therapy of obesity.

Contraindications

It is highly undesirable to take the drug in case of heart rhythm disturbance, with ischemia, with decompensated hypertension, with mental disorders.

Prescribing with Caution

With caution, you need to prescribe the drug against the background of such conditions as hypokalemia and hypomagnesemia, as well as in violation of the functions of the liver and kidneys. Special indication for women: when using the product, contraception should be carefully monitored.

Side effects

Insomnia, dry mouth, itchy skin, dizziness, thrombocytopenia, migraines, bleeding, edema, irritability, nausea, dysmenorrhea. There are also violations of the digestive and cardiac systems. In cardiac patients, sibutramine increases the number of heart attacks and, accordingly, the number of deaths.

The danger of sibutramine: in some patients with mental lability, regardless of the presence of cardiovascular diseases, a long ( for more than two years) taking the drug can lead to suicidal tendencies.

Dosage

1 capsule per day ( the beginning of therapy - 10 mg; with poor tolerance - reduce the dosage by half). If a month has passed since the start of treatment, and body weight has not decreased by 5%, then the dosage can be increased by 5 mg. The duration of treatment should not exceed 90 days in those patients whose body does not respond well to treatment, as a result of which a 5% decrease in body weight is not observed.

The total duration of treatment should not exceed two years.

Features of the drug

The action of the drug leads to a decrease in salivation, and this harms the teeth, which eventually form caries.
The drug can provoke the appearance of candidiasis, and some periodontal diseases.
Against the background of taking a means for losing weight, you need to reduce alcohol consumption to a minimum.
When working, which requires increased concentration of attention, for example, when driving a vehicle, it is undesirable to take the drug.
You can take Reduxin only after consulting a doctor. As a rule, doctors prescribe it in cases where other measures to reduce body weight do not justify themselves. You can not take the drug and at the same time do not adjust the eating behavior - this will only worsen the situation. Together with nutritionists, you need to choose a diet, develop a set of suitable physical activities, and change eating habits. This drug makes sense to take only as part of complex therapy.

Reduxin Light

Since Reduxin contains the substance sibutramine, which has an extensive list of adverse reactions, it is released in pharmacies only by prescription. Therefore, Reduxin Light was developed, which is sold without a prescription, since it contains absolutely safe substances. Unlike Reduksin, it is a dietary supplement.

Release form and content

The drug Reduxin Light is available in the form of capsules. The capsule shell consists of the following excipients: gelatin, purified water, glycerin, citric acid. One capsule contains 500 mg of conjugated linoleic acid.

What will help you lose weight?

An important assistant in the fight against excess weight is linoleic acid, which belongs to the group of essential fatty acids. They are irreplaceable because the human body does not produce these acids on its own - it receives them only from the outside. Reduxin Light is involved in the formation of a feeling of hunger, and when it enters the body, a kind of satiety indicator turns on. Modern ways of storing products, methods of their preparation, the process of preservation - all this disrupts metabolic processes. The feeling of fullness appears much later than expected. The amount of food necessary for proper digestion has already been eaten, and the person still feels hungry and continues to eat, which leads to the consumption of excess food. In turn, this leads to excess weight gain.

Most nutritionists respond positively to the use of the Reduxin Light supplement. Thanks to linoleic acid, which is in a conjugated state, the body physiologically correctly distributes energy and nutrients. Favorable energy conditions are created, and the work of the whole organism is normalized due to the correct release of body fat.

Application

To achieve good indicators of weight loss, the drug must be taken within two months. Accompany taking the drug should be a balanced diet. A nutritionist can help you formulate it in such a way as to reduce the content of foods that contain linoleic acid. This is done so that the body receives a dosed, and not an excessive amount of linoleic acid. The daily dosage of Reduxin Light is two capsules with meals, daily, for two months, as a supplement to the usual diet. To maintain a positive result, it is recommended to take the drug systemically and cyclically repeat the course of application at regular intervals, three to four times a year.

Even at the initial stage of the course, results will already appear in the form of a decrease in body fat and a simultaneous increase in muscle mass. The formation of a sports silhouette occurs precisely due to the combustion of fat in the muscles.

Pharmacokinetics

To speed up the process of burning fat, you need to combine the right diet with exercise. Physical activity will help get rid of fat on the hips, waist, abdomen. The scourge of modern men is the “beer belly”, which is formed from the immoderate consumption of beer against the background of physical inactivity and a genetic tendency to be overweight.

The use of the drug prevents the secondary deposition of subcutaneous fat, and helps to avoid a rebound effect. This is due to the linoleic acid it contains. Natural linoleic acid is found in meat and milk, in vegetable oils. Industrial extraction of this substance is carried out from safflower oil. Conjugated linoleic acid, entering the body, activates fermentation, due to which fat is processed, and also blocks the process of new accumulation of subcutaneous fat. There is an improvement in metabolism, which, in fact, is nothing more than the ability of the body to burn the calories received, extracting from this the energy necessary to maintain life. Acceleration of calorie burning leads to the fact that spare fat deposits cease to be unnecessary organic ballast and are gradually drawn into the metabolic process.

The additional energy received is used by the body to strengthen muscle tissue and to synthesize proteins.

Indications

Weight loss in obesity and related diseases cardiovascular, endocrine, digestive).

Contraindications

Children under 18 years old.
Pregnant women.
Lactating women.

Dosage

Drink 1 - 2 capsules of dietary supplement during meals, for two months. A second course can be carried out after a break of 2 - 3 months.

The optimal dose of linoleic acid to obtain maximum efficiency from Reduxin Light is 2.5 g per day - this corresponds to 4-6 capsules of the drug per day.

Side effects

With the correct dosage - not detected. Supplements are considered absolutely harmless.

Price

A package of Reduxin Light 625 mg containing 30 capsules costs approximately $30-$35. A package of Reduxin 10 mg containing 30 capsules costs $50 - $60; pack of 15 mg 30 capsules - 70 - 80 dollars.

Analogues

Analogue Reduksina Light: KLK 1000.
Reduksin's analogs: Lindax, Goldline, and Meridia ( the latter was withdrawn from pharmacies in European countries and banned for use).

If you are interested in how to take Reduxin 15 mg to lose weight, then you should know and remember that experts recommend drinking pills only for obese people - then the effect of the drug will not adversely affect health, and the feeling of satiety created will allow the body to lose weight. Familiarize yourself with the composition of the drug, find out what contraindications this fat-burning medicine has.

What is Reduxin 15 mg

Reduxin 15 mg is a combined drug that not only promotes weight loss, but also simultaneously increases the amount of HDL in the blood, due to which the level of uric acid and cholesterol in the body decreases and the number of triglycerides is significantly reduced. The main components of Reduxin are sibutramine and microcrystalline cellulose.

According to the manufacturer of this medication (and this is also confirmed by the reviews of those who lose weight and lose weight), this medication helps well for weight correction: it helps to reduce a person's need for food, while it quickly increases the feeling of satiety and thermal production. When buying Reduxin capsules for weight loss, it is important not to forget that treatment with their help should occur only with the participation of a dietitian.

Composition of Reduksin

According to the reviews of those who lose weight, when taking the drug, they feel high activity, slight euphoria and at the same time do not feel hunger at all. All this is explained by the fact that Reduxin contains the following components:

Sibutramine- the main active ingredient. Sibutramine is ideal for weight loss, because its action is aimed at reducing appetite, reducing hunger, in general, so that a person prone to overeating consumes fewer calories. In addition to affecting the satiety center in the brain, the substance differs in its effect on adrenoreceptors, due to which the breakdown of fat cells occurs. Further, fatty acids are converted into energy, and the resulting water and glycerol are excreted from the body.
Microcrystalline cellulose- a substance that, when it enters the stomach, swells strongly, due to which a person eats up a smaller portion. Swelling, cellulose absorbs a huge amount of water and additionally “picks up” harmful substances, but this causes not only a lack of appetite, but also intense thirst.

Indications for the use of Reduxin

The domestic drug is becoming increasingly popular among nutritionists who help their patients in the fight against excess weight. According to the manufacturer, indications for the use of Reduxin are as follows:

with alimentary obesity, if the body mass index exceeds 30 kilograms per 1 sq. m.;
with alimentary obesity, in the case when the body mass index is 27 kg / sq. m., but dyslipidemia or diabetes mellitus is still observed.

Application instruction of Reduksin of 15 mg

Regarding the dosage of the drug, the patient must follow the recommendations of his doctor, who, before prescribing a dosage, must necessarily conduct appropriate studies and send him for testing. Another important factor for determining the norm is the degree of obesity of a person who needs to take Reduxin. The instructions for the use of Reduxin 15 mg say that the capsule should be drunk once a day in the morning, and it doesn’t matter whether it is with meals or on an empty stomach - the effectiveness of the drug will not decrease. You can drink a Reduxin tablet with water.

Patients who started taking Reduxin tablets to lose weight are first given a small dose, then, depending on the effectiveness and individual tolerance, it can be changed. For example, it is recommended to switch to a dosage of Reduxin 15 mg after passing the first stage of treatment - a month of taking 10 mg tablets, if the course did not give the desired result in losing weight.

How to take Reduxin 15 mg to lose weight

15 mg is a safe dosage for weight loss. However, for the active burning of fat cells, it is recommended to make a change in lifestyle and diet: include sports every day, give up fried and fatty foods, sweets. The diet should contain more vegetables, low-fat dairy products, fruits, fish, berries. It is advisable to start taking the medicine with 10 mg tablets. If in a month you did not manage to lose more than 2 kg, then the dosage increases to 15 mg. Check out the simple rules on how to properly take Reduxin 15 mg to lose weight:

drink the capsule in the morning on an empty stomach with 200 ml of plain water;
the minimum course of treatment is 3 months, but if during the time of taking the pills the weight began to increase, then the treatment should be immediately interrupted.

Course duration

The drug should be taken, taking into account the initial weight and general health. Often, the duration of the course of taking Reduxin at a dosage of 15 mg does not exceed 3 months. As women (and men) who are losing weight from a lot of weight say, the course can last longer - up to 6 months, but you need to take the medication under the supervision of a doctor. It is worth noting that you need to drink pills to lose weight only when nothing else helps. This also applies to analogues of Reduksin.

Reduxin's contraindications

The manufacturer warns that the use of this medicine is prohibited if you are hypersensitive to the active ingredient sibutramine or other components, during pregnancy, during the period of feeding a baby, if you are under 18 or over 65 years old. In addition, Reduxin's contraindications include:

thyrotoxicosis;
bulimia, anorexia;
hypothyroidism (obesity of organic type);
pheochromocytoma;
mental illness;
severe disorders of the kidneys, liver;
angle-closure glaucoma;
vascular disease, heart disease.

Reduxin is highly discouraged from being combined with any drugs that belong to MAO inhibitors, with hypnotic drugs containing tryptophan, with neuroleptics and other drugs that affect human central nervous system receptors. The number of drugs incompatible with Reduxin also includes those that are used to treat obesity and those with which the patient struggles with mental pathologies.

Side effects of Reduxin

After reviewing the instructions on how to take Reduxin 15 mg to lose weight, it is also important to know how taking pills threatens the body, because such a high dosage can be dangerous for the body and disrupt metabolic processes. After self-administration of the drug, in addition to such unpleasant symptoms as dry mouth and a strong feeling of thirst, other side effects of Reduxin can be observed:

unmotivated outbursts of aggression;
psychosis or a state with suicidal thoughts (in such a situation, the doctor should immediately prohibit the use of the medicine);
insomnia;
impotence, problems with orgasm, ejaculation;
complete loss of appetite;
uterine bleeding, violation of the cycle of menstruation;
lack of coordination;
diarrhea and vomiting;
from the nervous system: short-term memory impairment, convulsions.

As for the sensations of a patient who has exceeded the recommended dose of Reduxin 15 mg, he may experience severe headaches, increased blood pressure, malaise, dizziness or tachycardia. In case of an overdose, a person can experience any of the above side effects, and to a pronounced degree. If any of the symptoms appear, stop taking the medicine and rush to the doctor.

Reduksin's analogs

For weight loss, not only Reduxin can be used, but also similar means - dietary supplements, the main thing is to choose an additive that is suitable in content. The price of Reduxin analogues can be both more expensive and cheaper than the original - the manufacturer already decides here, for example, dietary supplements from the manufacturer Globul have a low cost. Another difference in price depends on the number of pills in the package. The analogues of Reduxin include funds with the following names:

Goldline;
Reductil;
Meridia;
Slimia;
Lindax.

As for Reduxin Light, this is a medication that is the exact opposite of its predecessor. It is recommended to take it with an active lifestyle or physical training. The drug contains linoleic acid, vitamin E and other elements. Active substances normalize metabolism, promote the breakdown of fats. The price for Reduxin Light is less than for regular Reduxin, because each of them has a different effect on the body.

The price of Reduxin 15 mg

The sale of the drug should be carried out only in pharmacies. Even if the price of Reduxin 15 mg in some dubious online store of Chinese goods is too cheap, you should refuse this purchase, because for such a promotion you can “undermine” your health. How much does Reduxin cost in a pharmacy? Its cost is quite affordable: a plate for 30 capsules costs about 2,700 rubles on average. It is worth noting that the drug is dispensed only by prescription, so if you decide that only pills will help you lose weight, be sure to visit a doctor.

You can also order Reduxin online: in Moscow and St. Petersburg, delivery is carried out quickly and at a minimal cost. Here are the approximate prices of the original medicine and Reduxin Light in different cities.